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これまで無害と考えられていたビールスがガンの発症、進行に関与？ CSHL Research Links Harmless Viruses And Cancer
http://www.medicalnewstoday.com/medicalnews.php?newsid=63683
CSHL Research Links Harmless Viruses And Cancer
Main Category: Cancer / Oncology News
Article Date: 24 Feb 2007 - 17:00 PST
これまで無害と考えられていたビールスが染色体不安定性(CIN, chromosomal instability)とガンに関与している可能性が有るとの研究結果。
このモデルによると、細胞を融合させるビールスによりガン化する可能性があると言う。
ビールスがCINの原因となる可能性があれば、これらのビールスを発見し，非活性化することで病気の発症を減らすことができるだろうという。
Research led by Cold Spring Harbor Laboratory (CSHL) may link viruses that have been considered harmless to chromosomal instability (CIN) and cancer. "If the model that we propose is correct, protecting the body against viruses, or preventing the cell fusion that they cause may decrease the frequency of cancers and prevent their progression," said CSHL's lead investigator Yuri Lazebnik.
According to this model, cells can be made cancerous by viruses that fuse cells. Fusion abruptly unites two or three cells under the same membrane, a change that triggers massive CIN and creates diverse cells whose properties change over time. The researchers found that some of these cells can become cancerous.
The model that the researchers propose suggests that the best hope for controlling cancer is its prevention. If viruses can cause CIN, identifying and inactivating these viruses would help to decrease the incidence of the disease. This prognosis is consistent with the successes of preventative immunization against hepatitis B and papilloma viruses, which both cause cancer. Lazebnik and his CSHL colleague Dominik Duelli estimate that at least 18 of 29 virus families that infect human cells have species that fuse cells, which implies that CIN and cancer might be caused by viruses, even those that are considered harmless.
CSHL Research Links Harmless Viruses And Cancer
Main Category: Cancer / Oncology News
Article Date: 24 Feb 2007 - 17:00 PST
これまで無害と考えられていたビールスが染色体不安定性(CIN, chromosomal instability)とガンに関与している可能性が有るとの研究結果。
このモデルによると、細胞を融合させるビールスによりガン化する可能性があると言う。
ビールスがCINの原因となる可能性があれば、これらのビールスを発見し，非活性化することで病気の発症を減らすことができるだろうという。
Research led by Cold Spring Harbor Laboratory (CSHL) may link viruses that have been considered harmless to chromosomal instability (CIN) and cancer. "If the model that we propose is correct, protecting the body against viruses, or preventing the cell fusion that they cause may decrease the frequency of cancers and prevent their progression," said CSHL's lead investigator Yuri Lazebnik.
According to this model, cells can be made cancerous by viruses that fuse cells. Fusion abruptly unites two or three cells under the same membrane, a change that triggers massive CIN and creates diverse cells whose properties change over time. The researchers found that some of these cells can become cancerous.
The model that the researchers propose suggests that the best hope for controlling cancer is its prevention. If viruses can cause CIN, identifying and inactivating these viruses would help to decrease the incidence of the disease. This prognosis is consistent with the successes of preventative immunization against hepatitis B and papilloma viruses, which both cause cancer. Lazebnik and his CSHL colleague Dominik Duelli estimate that at least 18 of 29 virus families that infect human cells have species that fuse cells, which implies that CIN and cancer might be caused by viruses, even those that are considered harmless.
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