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血管形成に関わる重要なメカニズムが明らかに：ガン細胞増殖阻止の決め手となるか Important Mechanism Identified In The Formation Of Blood Vess
http://www.medicalnewstoday.com/medicalnews.php?newsid=61906
Important Mechanism Identified In The Formation Of Blood Vessels
Main Category: Biology / Biochemistry News
Article Date: 31 Jan 2007 - 23:00 PST
新しい血管は既存の血管から”芽”がでて a shoot sprouts形成される。このプロセスは"血管形成angiogenesis"と呼ばれるが、胎児の成長や正常な組織形成例えば、傷の治癒、メンスのサイクル等に関連して重要である。しかし、これは同時に、ガンや慢性の炎症性疾患といった病的組織形成においても決定的に重要な役割を果たす。
病的な血管形成抑制は多様な病気の治療に関して非常に魅力的なターゲットである。
腫瘍は新たな血管が存在しなければ、1,2ミリ以上成長することはできない。
これまで、亢血管形成療法は結腸がんや一般的な眼病であるAMD(加齢による網膜黄斑劣化）の治療に有効であることが明らかになっている。
全ての治療は成長ファクターVEGF（血管内皮成長ファクター）を対象としてきている。
スウェーデンのこの研究はVEGFとして新たにDll4 (Delta-like 4) が血管形成に関して同様な基本的役割を果たすことを明らかにした。
この研究でDll4信号パスウェイ？(Dll4 signalling）は親の血管から発芽する芽の数を決定することが明らかとなった。
これは形成される枝とリンクの数と血管の正しい厚さを決める上で決定的に重要である。血管供給が多すぎても少なすぎても、結果は破滅的であるから。
All tissues, sick and healthy alike, need a blood supply to survive and grow. The key to many medical problems, like preventing tumour development, is therefore to obstruct the spread of the blood vessels. Research scientists at Karolinska Institutet have now discovered a heretofore unknown mechanism for how the body links together its blood vessels.
New blood vessels are formed when a "shoot" sprouts from an already existing vessel. These shoots lengthen, branch off and contact other vessels as they form communicating networks of channels.
The process is called "angiogenesis" and is important in foetal development and normal tissue formation in connection with the healing of wounds, the menstrual cycle and so on.
However, it also plays a critical part in morbid tissue formation, such as cancer and chronic inflammatory diseases.
The inhibition of morbid angiogenesis therefore has very attractive therapeutic potential for a variety of diseases.
Tumours, for instance, can grow no larger than 1 or 2 mm without new blood vessels, upon which they are dependent for their proliferation.
To date, anti-angiogenic therapy has proved effective in the treatment of colon cancer and the common eye disease AMD (Age-dependent Macula Degeneration).
All therapies have so far targeted the growth factor VEGF (Vascular Endothelial Growth Factor). VEGF controls several important functions during the formation of blood vessels by signalling via receptors on the surface of the endothelial cells, the specialised layer of cells on the interior surface of the blood vessels.
Swedish scientists at Karolinska Institutet and the biotech company AngioGenetics AB have now shown that another factor called Dll4 (Delta-like 4) has a similarly fundamental role in blood vessel formation as VEGF. The results are published in Nature no. 28 (January 2007) and can mean that Dll4 is just as important a target for anti-angiogenic drugs as VEGF.
"We can now develop ways of boosting the effect of existing anti-angiogenic therapies, and maybe we can even start to treat tumour types that do not currently respond to anti-angiogenic drugs," says Mats Hellstrom, one of the scientists involved in the study.
The researchers have found that Dll4 signalling determines how many sprouts bud off from the parent vessel.
This principle is critical to the number of branches and links that form and to attaining the correct density of vessels. Too great a blood supply to a tissue is just as devastating as too little.
Important Mechanism Identified In The Formation Of Blood Vessels
Main Category: Biology / Biochemistry News
Article Date: 31 Jan 2007 - 23:00 PST
新しい血管は既存の血管から”芽”がでて a shoot sprouts形成される。このプロセスは"血管形成angiogenesis"と呼ばれるが、胎児の成長や正常な組織形成例えば、傷の治癒、メンスのサイクル等に関連して重要である。しかし、これは同時に、ガンや慢性の炎症性疾患といった病的組織形成においても決定的に重要な役割を果たす。
病的な血管形成抑制は多様な病気の治療に関して非常に魅力的なターゲットである。
腫瘍は新たな血管が存在しなければ、1,2ミリ以上成長することはできない。
これまで、亢血管形成療法は結腸がんや一般的な眼病であるAMD(加齢による網膜黄斑劣化）の治療に有効であることが明らかになっている。
全ての治療は成長ファクターVEGF（血管内皮成長ファクター）を対象としてきている。
スウェーデンのこの研究はVEGFとして新たにDll4 (Delta-like 4) が血管形成に関して同様な基本的役割を果たすことを明らかにした。
この研究でDll4信号パスウェイ？(Dll4 signalling）は親の血管から発芽する芽の数を決定することが明らかとなった。
これは形成される枝とリンクの数と血管の正しい厚さを決める上で決定的に重要である。血管供給が多すぎても少なすぎても、結果は破滅的であるから。
All tissues, sick and healthy alike, need a blood supply to survive and grow. The key to many medical problems, like preventing tumour development, is therefore to obstruct the spread of the blood vessels. Research scientists at Karolinska Institutet have now discovered a heretofore unknown mechanism for how the body links together its blood vessels.
New blood vessels are formed when a "shoot" sprouts from an already existing vessel. These shoots lengthen, branch off and contact other vessels as they form communicating networks of channels.
The process is called "angiogenesis" and is important in foetal development and normal tissue formation in connection with the healing of wounds, the menstrual cycle and so on.
However, it also plays a critical part in morbid tissue formation, such as cancer and chronic inflammatory diseases.
The inhibition of morbid angiogenesis therefore has very attractive therapeutic potential for a variety of diseases.
Tumours, for instance, can grow no larger than 1 or 2 mm without new blood vessels, upon which they are dependent for their proliferation.
To date, anti-angiogenic therapy has proved effective in the treatment of colon cancer and the common eye disease AMD (Age-dependent Macula Degeneration).
All therapies have so far targeted the growth factor VEGF (Vascular Endothelial Growth Factor). VEGF controls several important functions during the formation of blood vessels by signalling via receptors on the surface of the endothelial cells, the specialised layer of cells on the interior surface of the blood vessels.
Swedish scientists at Karolinska Institutet and the biotech company AngioGenetics AB have now shown that another factor called Dll4 (Delta-like 4) has a similarly fundamental role in blood vessel formation as VEGF. The results are published in Nature no. 28 (January 2007) and can mean that Dll4 is just as important a target for anti-angiogenic drugs as VEGF.
"We can now develop ways of boosting the effect of existing anti-angiogenic therapies, and maybe we can even start to treat tumour types that do not currently respond to anti-angiogenic drugs," says Mats Hellstrom, one of the scientists involved in the study.
The researchers have found that Dll4 signalling determines how many sprouts bud off from the parent vessel.
This principle is critical to the number of branches and links that form and to attaining the correct density of vessels. Too great a blood supply to a tissue is just as devastating as too little.
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ishida |
Latest page update: made by ishida
, Feb 7 2007, 8:07 AM EST
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436 words added view changes - complete history) |
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Keyword tags:
angiogenesis
AngioGenetics AB
blood vessels
chronic inflammatory diseases
Delta-like 4
DII4
growth factor
morbit angiogenesis
shoot sprouts
vascular endothelial
VEGF
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